Containing 90% of all botanic species found in Tanzania with one third classified as unique in the world.

The reserve is also home to the Mkomazi Rhino Project. This involves the reintroduction of four black rhino from South Africa which, it is hoped, will breed before being relocated to traditional natural habitats within Tanzania .

The Captive Breeding Programme for the African wild dog is another project for the preservation of endangered species that is based in Mkomazi.